Regeneron Stock Tumbles 12% After Experimental Cancer Drug Misses Key Trial Goal

Aditya Raghunath4 minute read
Reviewed by: Thomas Richmond
Last updated May 19, 2026

Key Stats for Regeneron Stock

  • Price change for Regeneron stock: -12%
  • $REGN Stock Price as of May. 18: $697
  • 52-Week High: $821
  • $REGN Stock Price Target: $867

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What Happened?

Regeneron (REGN) stock dropped sharply on Monday after the company disclosed that its experimental combination of melanoma drugs failed a key late-stage trial.

  • The combination of fianlimab and cemiplimab — sold as Libtayo — did not reach statistical significance in improving progression-free survival compared to Merck’s Keytruda in patients with advanced melanoma.
  • In plain terms, the drug showed a roughly five-month improvement over Keytruda, but the difference wasn’t large enough to be considered statistically meaningful.
  • That distinction matters enormously to regulators and investors.

At least ten brokerages cut their price targets on Regeneron stock following the news. BMO analyst Evan Seigerman summed up the mood bluntly, noting that back-to-back pipeline misses increase pressure on the company’s development over the next 12 to 18 months.

REGN Stock Revenue, EBIT and Free Cash Flow Estimates in Billion USD (TIKR)

This isn’t Regeneron’s first recent setback.

The company has also faced regulatory delays for a pre-filled syringe version of its eye drug Eylea, and suffered a late-stage failure of its lung drug itepekimab last year.

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What the Market Is Telling Us About Regeneron Stock

The reaction to Regeneron stock is severe but somewhat understandable.

Melanoma was supposed to be a major commercial opportunity for the fianlimab combination. Missing the primary endpoint compared with the market-leading Keytruda eliminates the near-term revenue story.

Regeneron does have a separate trial comparing fianlimab against Bristol Myers Squibb’s Opdualag. However, at least two analysts say they have low confidence in a positive result there, either.

REGN Stock Valuation Model (TIKR)

To be fair, Regeneron’s core business remains strong.

  • Q1 revenue grew 19% year-over-year to $3.6 billion.
  • Dupixent hit $4.9 billion in quarterly sales, up 31% on a constant currency basis.
  • The company also announced a new $3 billion share buyback program.

But for now, Regeneron stock is being judged on its pipeline, not its fundamentals.

Separately, the company announced a partnership with Parabilis Medicines with up to $2.2 billion in potential milestone payments — a small positive amid the noise.

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Disclaimer:

Please note that the articles on TIKR are not intended to serve as investment or financial advice from TIKR or our content team, nor are they recommendations to buy or sell any stocks. We create our content based on TIKR Terminal’s investment data and analysts’ estimates. Our analysis might not include recent company news or important updates. TIKR has no position in any stocks mentioned. Thank you for reading, and happy investing!

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