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Merck Stock Gains 13% As Experimental Melanoma Vaccine Trial With Moderna Meets Key Goals

Aditya Raghunath4 minute read
Reviewed by: David Hanson
Last updated Aug 20, 2026

@vladeep via Canva, @MariaBrzostowska from Getty Images via Canva

Key Stats for Merck Stock

  • Price change for Merck stock in last 6 months: 24%
  • $MRK Stock Price as of Aug. 19: $152
  • 52-Week High: $154
  • $MRK Stock Price Target: $138

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What Happened?

Merck (MRK) stock climbed more than 12% on Wednesday after Merck and Moderna announced strong results from their first-ever late-stage trial of a personalized cancer vaccine.

The shot, paired with Merck’s blockbuster immunotherapy Keytruda, hit its main goal in a Phase 3 study of over 1,100 melanoma patients who had already had their tumors surgically removed.

The combination significantly extended the time patients went without their melanoma coming back, compared to Keytruda alone. It also lowered the risk of the cancer spreading to other parts of the body. These results build on positive Phase 2 data the companies shared earlier this year.

Dr. Dean Li, president of Merck Research Laboratories, said the companies expect to start talking with regulators about the treatment “in the next few months.” Merck’s Dr. Jane Healy called the results “very exciting,” pointing out that the improvement over Keytruda alone was “clinically meaningful” and that patients tolerated the treatment well, with side effects similar to other common vaccines.

MRK Stock Revenue, EBIT and Free Cash Flow Estimates in Billion USD (TIKR)

The vaccine takes a personalized approach.

Instead of a one-size-fits-all treatment, it targets the specific mutations found in each patient’s tumor.

It trains the immune system to recognize and destroy those unique markers, then pairs that response with Keytruda to help the body fight the cancer more effectively. Healy noted this validates an approach Merck and Moderna have spent decades developing.

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What the Market Is Telling Us About Merck Stock

Merck stock’s 13% jump is a big move for a company this size, and it shows investors see real value in this data.

While the percentage gain looks smaller next to Moderna’s 177% surge, that difference mostly comes down to size. Merck entered the week worth around $333 billion, so a win like this adds real dollars even if the percentage move looks modest by comparison.

For Merck, this trial is one piece of a much bigger picture. The company is already generating strong growth from Keytruda and other newer products, and management has pointed to a large pipeline of new treatments they expect to drive growth for years.

A positive melanoma readout adds another potential growth driver, since Merck and Moderna are also testing the same vaccine in lung, bladder, and kidney cancers.

MRK Stock Valuation Model (TIKR)

Melanoma makes up only about 1% of skin cancers but causes a large share of skin cancer deaths, so a new treatment option matters.

The market’s reaction suggests investors view this less as a one-off event and more as proof that Merck stock has real upside tied to its oncology pipeline beyond Keytruda alone.

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Disclaimer:

Please note that the articles on TIKR are not intended to serve as investment or financial advice from TIKR or our content team, nor are they recommendations to buy or sell any stocks. We create our content based on TIKR Terminal’s investment data and analysts’ estimates. Our analysis might not include recent company news or important updates. TIKR has no position in any stocks mentioned. Thank you for reading, and happy investing!

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